Professor Geoff McFadden

Research Interests

• The relict chloroplast of malaria parasites
• Origin and evolution of plastids and mitochondria

Research Group

• Molecular & Cellular Evolution

Publications

1. Ralph, S.A., van Dooren, G.G., Waller, R.F., Crawford|, M.J., Fraunholz, M., Foth, B.F., Tonkin, C.J., Roos, D.S., and McFadden, G.I. (2004). Metabolic maps and functions of the Plasmodium falciparum apicoplast. Nature Reviews Microbiol 2, 203-216.
2. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S., et al. (2002). Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511.
3. Gilson, P.R., and McFadden, G.I. (2001). Genome sequencing. A grin without a cat. Nature 410, 1040-1041.
4. Waller, R.F., Reed, M.B., Cowman, A.F., and McFadden, G.I. (2000). Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway. Embo J 19, 1794-1802.
5. Beech, P.L., Nheu, T., Schultz, T., Herbert, S., Lithgow, T., Gilson, P.R., and McFadden, G.I. (2000). Mitochondrial FtsZ in a chromophyte alga. Science 287, 1276-1279.
6. McFadden, G.I. (1999). Chloroplasts - Ever decreasing circles. Nature 400, 119-120.
7. Keeling, P.J., Palmer, J.D., Donald, R.G.K., Roos, D.S., Waller, R.F., and McFadden, G.I. (1999). Shikimate pathway in apicomplexan parasites. Nature 397, 219-220.
8. Waller, R.F., Keeling, P.J., Donald, R.G.K., Striepen, B., Handman, E., Langunnasch, N., Cowman, A.F., Besra, G.S., Roos, D.S., and McFadden, G.I. (1998). Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc. Natl Acad. Sci. USA 95, 12352-12357.
9. McFadden, G.I., Reith, M.E., Munholland, J., and Lang-Unnasch, N. (1996). Plastid in human parasites. Nature 381, 482.
10. Foth, B.J., Ralph, S.A., Tonkin, C.J., Struck, N.S., Fraunholz, M., Roos, D.S., Cowman, A.F., and McFadden, G.I. (2003). Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science 299, 705-708.
11. Ralph, S.A., D'Ombrain, M.C., and McFadden, G.I. (2001). The apicoplast as an antimalarial drug target. Drug Resist Updates 4, 145-151.
12. McFadden, G.I., and Roos, D.S. (1999). Apicomplexan plastids as drug targets. Trends Microbiol. 6, 328-333.
13. Bender, A., van Dooren, G.G., Ralph, S.A., McFadden, G.I., and Schneider, G. (2003). Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum. Mol Biochem Parasitol 132, 59-66.
14. van Dooren, G.G., Su, V., D'Ombrain, M.C., and McFadden, G.I. (2002). Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme. J Biol Chem 277, 23612-23619.
15. Waller, R.F., Ralph, S.A., Reed, M.B., Su, V., Douglas, J.D., Minnikin, D.E., Cowman, A.F., Besra, G.S., and McFadden, G.I. (2003). A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob Agents Chemother 47, 297-301.
16. Waller, R.F., Keeling, P.J., van Dooren, G.G., and McFadden, G.I. (2003). Comment on "A green algal apicoplast ancestor". Science 301, 49.
17. Foth, B.J., Stimmler, L.M., Handman, E., Crabb, B.S., Hodder, A.N., and McFadden, G.I. (2005). The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol 55, 39-53.
18. McMillan, P.J., Stimmler, L.M., Foth, B.J., McFadden, G.I., and Muller, S. (2005). The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases. Mol Microbiol 55, 27-38.